Genetic and Molecular Basis of Longevity

The summary for the Genetic and Molecular Basis of Longevity grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Genetic and Molecular Basis of Longevity: The National Institute on Aging (NIA) invites applications for new and competing renewal applications for research project grants (R01) to support basic research on the genetic and molecular basis of longevity. The goals of the "Genetic and Molecular Basis of Longevity" Request for Applications (RFA) are to identify and functionally characterize genes that play a role in determining and modulating longevity and health span and determine the molecular mechanism(s) of action of these Longevity Assurance Genes (LAGs). Longevity Assurance Genes are operationally defined as genes that: determine, modulate or promote longevity and extend health span; maintain cell, tissue and/or organ function; and regulate and/or maintain organismal homeostasis. A multidisciplinary approach to the study of the complex traits of aging and longevity, including the application of genetic, molecular and biochemical approaches and techniques, has significantly accelerated research progress toward an in depth understanding of the genes, proteins, and biochemical pathways that modulate and play significant functional roles in aging and longevity in both invertebrate and mammalian species. Candidate LAGs that fit one or more of the above classifications have been identified in several invertebrates (Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans), mice and humans. The continued development and application of multidisciplinary scientific approaches to the elucidation of the genetic and molecular basis of aging and longevity is strongly encouraged in applications submitted in response to this RFA.