The National Institute on Aging Multicenter Study on Exceptional Survival in Families (U01)

The summary for the The National Institute on Aging Multicenter Study on Exceptional Survival in Families (U01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

The National Institute on Aging Multicenter Study on Exceptional Survival in Families (U01): The National Institute on Aging (NIA) invites applications for cooperative agreements (UO1s) to participate in the design and implementation of a Multicenter Study on Exceptional Survival in Families (ESF). This study will determine the degree and patterns of familial transmission and aggregation of exceptional longevity and healthy survival to advanced age as characterized by a variety of phenotypic measures. This Request for Applications (RFA) solicits proposals for: (1) Study Centers to design and implement the ESF study, and (2) a Data Management and Coordinating Center (DMCC) that will interact with the Study Centers, a Steering Committee, a Monitoring Board, and NIA staff by providing administrative, logistical, and data management support for the ESF Study. Exceptional longevity (i.e., survival to extreme old age) is one of a set of favorable exceptional survival outcomes, including unusually long survival before the occurrence of significant morbidity ("health span") or disability (active life expectancy). This set of outcomes is referred to in this document as "exceptional survival" (ES). Understanding the factors that contribute to ES could lead to better understanding of contributors to long and healthy life in humans in general, not just the very old. In view of evidence that exceptional longevity is associated with other ES outcomes and shows a pattern of familial aggregation, information from exceptionally long- lived families provides a starting point for identifying patterns of and appropriate measures for exceptional survival. Results of the ESF study will provide a better understanding of the degree and patterns of familial aggregation of ES outcomes. In addition, the data from the ESF study will provide a strong information-base on the characteristics of exceptionally long-lived families that will aid in identifying research strategies that are likely to be successful for future studies on factors contributing to exceptional survival. This is a one-time solicitation to support the Study Centers and the DMCC for 5 years. The DMCC and a participating Study Center may be located at the same Institution, however each must be administratively and fiscally distinct from the other.